We demonstrate how different normalization techniques in GC‐MS analysis impart unique properties to the data, influencing any biological inference. Using simulations, and empirical data, we compare the most commonly used techniques (Total Sum Normalization ‘TSN’; Median Normalization ‘MN’; Probabilistic Quotient Normalization ‘PQN’; Internal Standard Normalization ‘ISN’; External Standard Normalization ‘ESN’; and a compositional data approach ‘CODA’). When differences between biological classes are pronounced, ESN and ISN provides good results, but are less reliable for more subtly differentiated groups. MN, TSN, and (...) CODA approaches produced variable results dependent on the structure of the data, and are prone to false positive biomarker identification. In contrast, PQN exhibits the lowest false positive rate, though with occasionally poor model performance. Because ESN requires extensive pre‐planning, and offers only mixed reliability, and ISN, TSN, MN, and CODA approaches are prone to introducing artefactual differences, we recommend the use of PQN in GC–MS research. (shrink)

The book roots corruption in the idea of a departure from conventional standards, and thus offers an account not only of its corrosiveness but also of its malleability and controversiality. In the course of a broadranging exploration, it examines various links between private and public corruption, connecting the latter with other social and political structures.

A new collection of essays edited by Michael J. Thompson aims to explicate and defend the humanist values which, according to the authors, were the core of Marx's critique of capitalist society. The text does not aim to provide a political roadmap to building an alternative society in which those values could be realized but rather philosophical analysis of the meaning and implications of those values. While there are sometimes tensions between the philosophical arguments developed in the various essays (...) that make up the text and the traditions of Marxist political practice, the book as a whole certainly proves that the human values of Marx's philosophy are central to his politics and that his emancipatory vision remains relevant, even necessary. (shrink)

Much has been published about the ethical issues encountered by clinicians in genetics/genomics, but those experienced by clinical laboratory scientists are less well described. Clinical laboratory scientists now frequently face navigating ethical problems in their work, but how they should be best supported to do this is underexplored. This lack of attention is also reflected in the ethics tools available to clinical laboratory scientists such as guidance and deliberative ethics forums, developed primarily to manage issues arising within the clinic.We explore (...) what ethical issues are being experienced by clinical scientists, how they think such issues could be best analysed and managed, and whether their practice might be enhanced by more situated approaches to ethics deliberation and practice such as ethical preparedness. From thematic analysis of cases presented by clinical scientists at a specially convened meeting of the UK Genethics Forum, we derived three main ethical themes: (1) the redistribution of labour and responsibilities resulting from the practice of genomic medicine; (2) the interpretation and certainty of results and (3) the proposal that better standardisation and consistency of ethical approaches (for example, more guidelines and policy) could resolve some of the challenges arising.We argue that although standardisation is important for promoting shared understandings of good (including ethical) practice, supplementary approaches to enhance and sustain ethical preparedness will be important to help clinical scientists and others in the recently expanded genetic/genomic medicine environment foster quality ethical thinking. (shrink)

The food industry faces many significant risks from public criticism of corporate social responsibility (CSR) issues in the supply chain. This paper draws upon previous research and emerging industry trends to develop a comprehensive framework of supply chain CSR in the industry. The framework details unique CSR applications in the food supply chain including animal welfare, biotechnology, environment, fair trade, health and safety, and labor and human rights. General supply chain CSR issues such as community and procurement are also considered. (...) Ultimately, the framework serves as a comprehensive tool to support food industry practitioners and researchers in the assessment of strategic and operational supply chain CSR practices. (shrink)

This paper is a response to Baumann's comments on "Can Knowledge Really be Non-fative?" In this paper Baumann's suggestions for how those who deny the factivty of knowledge might deal with the argument from inconsistency and explosion are addressed.

_The Metaphysics of Perfect Beings_ addresses the problems an Anselmian perfect being faces in contexts involving unlimited options. Recent advances in the theory of vagueness, the metaphysics of multiverses and hyperspace, the theory of dynamic or sequential choice, the logic of moral and rational dilemmas, and metaethical theory provide the resources to formulate the new challenges and the Anselmian responses with an unusual degree of precision. Almeida shows that the challenges arising in the unusual contexts involving unlimited options sometimes produce (...) metaphysical surprise. (shrink)

This is an editorial introduction to a special issue of Acta Analytica on epistemic luck.

The paper examines the problematic understanding of “risk” in entrepreneurial literature that locates courage in either the loss orgain of having or in the difficulty and hardship of the doing. We argue in this paper that what is lost in this vernacular view of courage is a deeper notion of the subjective dimension of work and the social need of society. Grounded within the Catholic social and moral tradition, we find a richer notion of courage, which in part corrects and (...) rounds out the insufficient description of the vernacular understanding of courage in entrepreneurship. What we also find in this account of the virtues and subjective dimension of work is greater explanatory power of what happens to the entrepreneur in the work that he or she does. The end result of this analysis is a more spiritual, ethical and social understanding of entrepreneurship. (shrink)

Some carnivores defend the position that the opportunistic consumption of meat is morally permissible even under the assumption that it is morally wrong to act in ways that ause unnecessary suffering to sentient beings. Ordering and consuming chicken once a week, they argue, will not increase the numbers of chickens suffering or slaughtered, since the system of purchasing and farming chickens is not sufficiently fine‐tuned to register differences at margin. We argue that, insensitivity of the market notwithstanding, consistent consequentialists are (...) morally prohibited from each additional purchase and consumption of meat. (shrink)

This paper criticizes the pragma-dialectical conception of a fallacy, according to which a fallacy is an argumentative speech act which violates one or more of the rules of 'rational discussion'. That conception is found to be neither a necessary nor a sufficient condition for committing a fallacy. It is also found wanting in several other respects.

Over the last decade a handful of cognitive models of religious belief have begun to coalesce in the literature. Attempts to offer “scientific explanations of religious belief ” are nothing new, stretching back at least as far as David Hume, and perhaps as far back as Cicero. What is also not new is a belief that scientific explanations of religious belief serve in some way to undermine the justification for those beliefs.

The paper examines the problematic understanding of “risk” in entrepreneurial literature that locates courage in either the loss orgain of having or in the difficulty and hardship of the doing. We argue in this paper that what is lost in this vernacular view of courage is a deeper notion of the subjective dimension of work and the social need of society. Grounded within the Catholic social and moral tradition, we find a richer notion of courage, which in part corrects and (...) rounds out the insufficient description of the vernacular understanding of courage in entrepreneurship. What we also find in this account of the virtues and subjective dimension of work is greater explanatory power of what happens to the entrepreneur in the work that he or she does. The end result of this analysis is a more spiritual, ethical and social understanding of entrepreneurship. (shrink)

Property-identical divine-command theory (PDCT) is the view that being obligatory is identical to being commanded by God in just the way that being water is identical to being H2O. If these identity statements are true, then they express necessary a posteriori truths. PDCT has been defended in Robert M. Adams (1987) and William Alston (1990). More recently Mark C. Murphy (2002) has argued that property-identical divine-command theory is inconsistent with two well-known and well-received theses: the free-command thesis and the supervenience (...) thesis. I show that Murphy's argument is vitiated by mistaken assumptions about the substitutivity of metaphysical identicals in contexts of supervenience. The free-command thesis and the supervenience thesis therefore pose no serious threat to PDCT. (Published Online August 11 2004). (shrink)

Van Fraassen’s (1989) infamous best of a bad lot objection is widely taken to be the most serious problem that afflicts theories of inference to the best explanation (IBE), for it alleges to show that we should not accept the conclusion of any case of such reasoning as it actually proceeds. Moreover, this is supposed to be the case irrespective of the details of the particular criteria used to select best explanations. The best of a bad lot objection is predicated (...) on, and really only requires, the idea that in any real case of IBE where one hypothesis is favored as best over those with which it competes, it is always the case that it is more likely that the true explanation is to be found in the set of unformulated and unconsidered logical alternatives to the set of actually considered hypotheses. On this basis, Van Fraassen believes that accepting the conclusion of IBEs so understood is irrational and this is simply because such inferences are supposedly not probative. In this paper the best of a bad lot objection will be addressed and it will be shown that Van Fraassen’s notorious criticism of IBE depends on a problematic conflation of two notions of rationality and thus that his criticism of IBE involves a damning equivocation. In essence, he conflates ideal standards of rationality with epistemic standards of rationality and, in so doing, makes it appear to be the case that we should not accept the conclusions of IBEs. But, when we disambiguate the concepts of rationality at work in the argument Van Fraassen’s conclusion simply does not follow. (shrink)

We highlight connections between accessible categories and abstract elementary classes , and provide a dictionary for translating properties and results between the two contexts. We also illustrate a few applications of purely category-theoretic methods to the study of AECs, with model-theoretically novel results. In particular, the category-theoretic approach yields two surprising consequences: a structure theorem for categorical AECs, and a partial stability spectrum for weakly tame AECs.

This paper introduces a new argument for the safety condition on knowledge. It is based on the contention that the rejection of safety entails the rejection of the factivity condition on knowledge. But, since we should maintain factivity, we should endorse safery.

This paper introduces a new argument against Richard Foley’s threshold view of belief. His view is based on the Lockean Thesis (LT) and the Rational Threshold Thesis (RTT). The argument introduced here shows that the views derived from the LT and the RTT violate the safety condition on knowledge in way that threatens the LT and/or the RTT.

In this paper it is argued that three of the most prominent theories of conditional acceptance face very serious problems. David Lewis' concept of imaging, the Ramsey test and Jonathan Bennett's recent hybrid view all face viscious regresses, or they either employ unanalyzed components or depend upon an implausibly strong version of doxastic voluntarism.

We develop a framework for assessing security market quality, relating five elements of market design to three metrics of market integrity and two metrics of market efficiency. We empirically implement this integrity–efficiency MQ framework by testing a hypothesis that trade-based ramping manipulation at the close raises execution costs on 24 security markets worldwide. Estimating a simultaneous equations model of ramping incidence, spreads, and the probability of deploying real-time surveillance, we show that quoted bid-ask spreads are positively related to the incidence (...) of MTC across seven liquidity deciles. The magnitude is economically significant; improving market integrity by cutting MTC in half reduces spreads 6–11 %. Allowing direct market access in conjunction with RTS, conducting auctions at the close, and developing regulations that require surveillance, all reduce MTC and thereby lower spreads, assuring better market integrity and enhancing market efficiency. Introducing circuit breakers or prohibiting shorts poses integrity–efficiency tradeoffs. (shrink)

Paradoxes have played an important role both in philosophy and in mathematics and paradox resolution is an important topic in both fields. Paradox resolution is deeply important because if such resolution cannot be achieved, we are threatened with the charge of debilitating irrationality. This is supposed to be the case for the following reason. Paradoxes consist of jointly contradictory sets of statements that are individually plausible or believable. These facts about paradoxes then give rise to a deeply troubling epistemic problem. (...) Specifically, if one believes all of the constitutive propositions that make up a paradox, then one is apparently committed to belief in every proposition. This is the result of the principle of classical logical known as ex contradictione (sequitur) quodlibetthat anything and everything follows from a contradiction, and the plausible idea that belief is closed under logical or material implication (i.e. the epistemic closure principle). But, it is manifestly and profoundly irrational to believe every proposition and so the presence of even one contradiction in one’s doxa appears to result in what seems to be total irrationality. This problem is the problem of paradox-induced explosion. In this paper it will be argued that in many cases this problem can plausibly be avoided in a purely epistemic manner, without having either to resort to non-classical logics for belief (e.g. paraconsistent logics) or to the denial of the standard closure principle for beliefs. The manner in which this result can be achieved depends on drawing an important distinction between the propositional attitude of belief and the weaker attitude of acceptance such that paradox constituting propositions are accepted but not believed. Paradox-induced explosion is then avoided by noting that while belief may well be closed under material implication or even under logical implication, these sorts of weaker commitments are not subject to closure principles of those sorts. So, this possibility provides us with a less radical way to deal with the existence of paradoxes and it preserves the idea that intelligent agents can actually entertain paradoxes. (shrink)

I provide a critique of Axel Honneth’s theory of recognition by calling into question the extent to which recognitive relations are immune to the effects of social and economic power and their ability to shape consciousness and moral cognition. I maintain that as a theory of socialization, Honneth’s theory is inadequate to deal with the strong structural-functional forces that hold administrative-capitalist societies together. This has the effect of constituting subjectivity in particular ways, and this problem of the constitution of the (...) personality and consciousness of individuals vitiates the descriptive and normative claims of the theory of recognition. I end by considering an alternative way to view recognition and its role in promoting a form of critical subjectivity. (shrink)

In recent years a number of sophisticated versions of soteriological universalism have appeared in the literature. In this essay I offer some critical retlections them. In particular, I argue that universalism offers no explanation for the fact that God puts human creatures through the earthly life, and that if there is no such reason then the earthly life and the evil it contains are both gratuitous. Finally, I argue that universalists are obliged to deny that human beings have a centrally (...) important feature of human freedom. (shrink)

This paper is an insighful critique of the shareholder and stakeholder models of organizational purpose. The authors emphasize that both these models fail to serve as an adequate basis for explaining the purpose of an organization and are unable to capture a fuller meaning of living in an organizational community. The paper thus endeavours to introduce into the mainstream of discussion a third model, based on the idea of the common good which draws inspiration from the communitarian Catholic tradition. The (...) first part of this paper traces the idea of common good as it relates to organizations. The second part engages the common good tradition with the shareholder and stake holder models. The paper goes on to describe common good within the organization through three propositions: fundamentality, excellence and integration. The authors reiterate, however, that the idea of the common good does not provide a micro-blueprint for managers, but rather an orientation or moral compass that directs organizational activity towards human development. (shrink)

The book gives a diverse and even-handed treatment of the topic without attempting to resolve the matter.

We introduce a family of rank functions and related notions of total transcendence for Galois types in abstract elementary classes. We focus, in particular, on abstract elementary classes satisfying the condition known as tameness, where the connections between stability and total transcendence are most evident. As a byproduct, we obtain a partial upward stability transfer result for tame abstract elementary classes stable in a cardinal $\lambda$ satisfying $\lambda^{\aleph_{0}}\gt \lambda$, a substantial generalization of a result of Baldwin, Kueker, and VanDieren.

In this article the standard philosophical method involving intuition-driven conceptual analysis is challenged in a new way. This orthodox approach to philosophy takes analysanda to be the specifications of the content of concepts in the form of sets of necessary and sufficient conditions. Here it is argued that there is no adequate account of what necessary and sufficient conditions are. So, the targets of applications of the standard philosophical method so understood are not sufficiently well understood for this method to (...) be dependable. (shrink)

This paper challenges Williamson's "E = K" thesis on the basis of evidential practice. The main point is that most evidence is only approximately true and so cannot be known if knowledge is factive.

In this paper I argue that the best explanation of expertise about taste is that such alleged experts are simply more eloquent in describing the taste experiences that they have than are ordinary tasters.

In this chapter we consider three philosophical perspectives (including those of Stalnaker and Lewis) on the question of whether and how the principle of conditional excluded middle should figure in the logic and semantics of counterfactuals. We articulate and defend a third view that is patterned after belief revision theories offered in other areas of logic and philosophy. Unlike Lewis’ view, the belief revision perspective does not reject conditional excluded middle, and unlike Stalnaker’s, it does not embrace supervaluationism. We adduce (...) both theoretical and empirical considerations to argue that the belief revision perspective should be preferred to its alternatives. The empirical considerations are drawn from the results of four empirical studies (which we report below) of non-experts’ judgments about counterfactuals and conditional excluded middle. (shrink)

It is wholly uncontroversial that measurements-or, more properly, propositions that are measurement reports-are often paradigmatically good cases of propositions that serve the function of evidence. In normal cases it is also obvious that stating such a report is an utterly pedestrian case of successful assertion. So, for example, there is nothing controversial about the following claims: (1) that a proposition to the effect that a particular thermometer reads 104C when properly used to determine the temperature of a particular patient is (...) evidence that the patient in question has a fever and (2) that there is nothing wrong with asserting the proposition that a particular thermometer reads 104C for appropriate reasons of communication, etc. when the thermometer has been properly used to determine the temperature of a particular patient. Here it will be shown that Timothy Williamson’s commitments to a number of principles about knowledge and assertion imply that a whole class of utterly ordinary statements like these that are used as evidence are not really evidence because they are not knowledge and so are (perversely) unassertable according to his principled commitments. This paper deals primarily with the second of these two problems and an alternative account of the norms of assertion is introduced which allows for the assertability of such measurement reports. (shrink)

In a recent revision (chapter 4 of Nowakowa and Nowak 2000) of an older article Leszek Nowak (1992) has attempted to rebut Niiniluoto’s 1990 critical suggestion that proponents of the Poznań idealizational approach to the sciences have committed a rather elementary logical error in the formal machinery that they advocate for use in the analysis of scientific methodology. In this paper I criticize Nowak’s responses to Niiniluoto’s suggestion, and, subsequently, work out some of the consequences of that criticism for understanding (...) the role that idealization plays in scientific methodology. (shrink)

I propose and outline an ethical theory of waste not as refuse or garbage, but rather as a property of activities and practices. On my account, waste results when resources are utilized in society in such a way that the maximum number of individuals within the community are unable to benefit from the collective resources and efforts of social activities. I point to three ethical “dimensions” of waste: socially unproductive activity, under-utilization of resources, and the mis-utilization or mis-direction of resources. (...) Each of these dimensions accounts for different kinds of practices and activities as well as institutional arrangements within any society. As I see it, waste emerges when those resources are employed and utilized in ways that do not maximize their potential benefits for what I term socially valid ends. In this sense, waste can be seen to adhere to practices, activities, and systems of production and consumption that do not benefit the largest possible share of the society. I end by considering the relevance of this ethical concept of waste for a broader theory of social justice. (shrink)

Standard dyadic deontic logic (as well as standard deontic logic) has recently come under attack by moral philosophers who maintain that the axioms of standard dyadic deontic logic are biased against moral theories which generate moral conflicts. Since moral theories which generate conflicts are at least logically tenable, it is argued, standard dyadic deontic logic should be modified so that the set of logically possible moral theories includes those which generate such conflicts. I argue that (1) there are only certain (...) types of moral conflicts which are interesting, and which have worried moral theorists, (2) the modification of standard dyadic deontic logic along the lines suggested by those who defend the possibility of moral conflicts makes possible only uninteresting types of moral conflicts, and (3) the general strategy of piecemeal modification standard dyadic deontic logic is misguided: the possibility of interesting moral conflicts cannot be achieved in that way. (shrink)

What forms of collective political action conceivably might offer the best prospects for radical, transformative change in the context of a planet currently in crisis, and characterized by intersecting struggles for environmental, economic, social, and racial justice? The concept of radical subjectivity that Herbert Marcuse developed throughout his life and work can provide social movement theorists, organizations and activists with valuable theoretical and practical resources to identify, encourage, and further develop new and emerging forms of political agency and activism, and (...) thereby contribute to the mobilization of contemporary social movements seeking to address these crises and their underlying causes. This concept, when critically reevaluated and appropriated in light of more recent insights about the nature of subjectivity and political agency as well as in the context of these contemporary struggles, can assist in the development of a theory and practice that might be adequate to address the multiple global crises currently confronting humanity and other forms of life on Earth. (shrink)

What forms of collective political action conceivably might offer the best prospects for radical, transformative change in the context of a planet currently in crisis, and characterized by intersecting struggles for environmental, economic, social, and racial justice? The concept of radical subjectivity that Herbert Marcuse developed throughout his life and work can provide social movement theorists, organizations and activists with valuable theoretical and practical resources to identify, encourage, and further develop new and emerging forms of political agency and activism, and (...) thereby contribute to the mobilization of contemporary social movements seeking to address these crises and their underlying causes. This concept, when critically reevaluated and appropriated in light of more recent insights about the nature of subjectivity and political agency as well as in the context of these contemporary struggles, can assist in the development of a theory and practice that might be adequate to address the multiple global crises currently confronting humanity and other forms of life on Earth. (shrink)